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ABOUT US

School:
Temasek Polytechnic
(Food Science & Nutrition)

Names
Alicia Chee(TA03)
Chin Ying(TA01)
Lynnette Heng(TA01)
Lorelle Ang(TA01)
Levina Tay(TA01)
Nicholas Tan(TA03)

Subject: PBPN

Topic:Immunology


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Saturday, February 6, 2010
~Causation of Autoimmune Disease~

Autoimmune diseases occur when some aspect of self-tolerance is lost by the self antigens & an adaptive immune response is directed towards normal components of the healthy human body leading to inflammation. This results to the production of more self antigens.

The response strives to rid the target antigens from the body and until that is achieved or the patient dies, a chronic state of information & lymphocyte infiltration exists in tissues where the target antigens are expressed. This severely damages & affect the function of the tissue.

Although the regulatory mechanisms of the immune system respond to the situation & can provide temporary relieve between episodes of disease, autoimmune diseases can rarely be cured. They are chronic diseases in which the immune response remains suspended in its destructive phase & never reaches reconstruction.

[Peter Parham. (2009). The Immune System 3rd Ed. London & New York: Garland Science Publishing; Charles A. Janeway, Jr., Paul Travers, Mark Walport, Mark J. Shlomchik. (2005) Immuno Biology 6th Ed. New Yolk & London: Garland Science Publishing]

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