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ABOUT US

School:
Temasek Polytechnic
(Food Science & Nutrition)

Names
Alicia Chee(TA03)
Chin Ying(TA01)
Lynnette Heng(TA01)
Lorelle Ang(TA01)
Levina Tay(TA01)
Nicholas Tan(TA03)

Subject: PBPN

Topic:Immunology


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Sunday, February 7, 2010
~Classification of Autoimmune Disease~

Autoimmune responses are similar to normal immune responses and pathogens in that they are specifically activated by antigens. In this case, self antigens or auto-antigens. The type of autoimmune disease stimulated when self-reactive lymphocytes are activated depends on their particular targets. Autoimmune diseases are divided into organ-specific & systemic.

For Type I Insulin-Dependent Diabetes Mellitus (IDDM), which is a organ specific type, it is caused by the immune attack on insulin-producing pancreatic beta cells, auto-antigens from one or a few organs are targeted & disease is therefore confined to those organs.

As for Systemic Lupus Erythematosus (SLE), it is a systemic type where chromatin is a major target. Hence, systemic autoimmune diseases affects multiple organs & have a tendency to become chronic, as the auto-antigens can never be removed from the body as it is present everywhere.

Reference
[Charles A. Janeway, Jr., Paul Travers, Mark Walport, Mark J. Shlomchik. (2005) Immuno Biology 6th Ed. New Yolk & London: Garland Science Publishing]

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